
Job offer:
Research Assistant at BMFTR-funded project “UncovRT”
We are seeking a PhD candidate in the field of computational medical physics (75%, TV-L E13, 3 years) to join our BMFTR-funded research project on molecular mechanisms of side effects after cranial proton therapy.
from 1 August 2026
The project will assess neurocognitive and neurovascular late effects in pediatric proton therapy. UncovRT: Uncover molecular mechanisms of side effects after cranial Radiation Therapy to improve quality of life for long term survivors of brain cancer.
Specifically, we plan to refine and expand the existing predictive models for contrast-enhancing lesions in pediatric patients with brain tumors who have undergone proton therapy. The research will be conducted within the framework of a national consortium. The opportunity to pursue a doctorate is offered. The doctorate is embedded in medical and medical physics research at the WPE and in the regional research landscape of the Ruhr universities, in particular the DFG-funded research training group 3043 AMTEC-PRO – Advanced Methods and Technologies for Proton Therapy.
West German Proton Therapy Centre Essen
Am Mühlenbach 1, 45147 Essen
Job Scope: 75 Percent
Start: 01.08.2026
Working at the University Medical Centre Essen
As a maximum-care university hospital with a capacity of around 1,300 beds, we treat 225,000 patients a year with over 6,000 employees in 26 clinics, 23 institutes and specialist centres. Our hospital offers medical care, state-of-the-art diagnostics and comprehensive treatment to the highest international standards. In addition, we offer a comprehensive range of research and teaching services at an internationally competitive level.


Working in the heart of the Ruhr region
In Essen, in the heart of the Ruhr region and the green capital of Europe in 2017, the WPE’s Particle Therapy Clinic offers a challenging field of work in the application of state-of-the-art proton therapy for the effective yet particularly gentle treatment of tumor diseases. Since 2013, the WPE has been successfully treating outpatients with CNS tumors, head and neck tumors, sarcomas, prostate carcinomas and childhood tumors with proton therapy. Since its opening, the WPE has acquired an excellent reputation recognized worldwide. Numerous collaborations at national and international level are proof of the high therapeutic and scientific standard of our work. The result: our patients come to us in Essen not only from all over Germany, but also from many other European and non-European countries. That is why we are looking for you to join our team.
Working at WPE
At our West German Proton Therapy Centre Essen (WPE), under the direction of Prof. Beate Timmermann, we offer state-of-the-art radiation therapy for tumor diseases using protons. The centerpiece of the facility is a 230 MeV cyclotron. The four treatment rooms contain three gantries that can be rotated through 360 degrees and a fixed-beam room with 2 fixed beam lines. Each of the rotating gantries weighs approximately 120 tons and yet ensures an accuracy of up to 0.25 degrees. The Pencil Beam Scanning method (PBS) and a state-of-the-art therapy planning system are used for Intensity Modulated Proton Therapy (IMPT). This means that the entire craniospinal axis (CSA, includes the brain and spinal canal) can be routinely irradiated in the WPE for tumors of the central nervous system (CNS). The availability of IMPT also enables a simultaneous integrated boost (SIB) – i.e. simultaneous boost irradiation.


“UncovRT”
The UncovRT project is conducting research on the impact of radiation therapy on quality of life. As part of the National Decade Against Cancer, the Federal Ministry of Research, Technology, and Space (BMFTR) is providing UncovRT with approximately two million euros in funding. Of this amount, 420,000 euros are going to the UME. The team at the Clinic for Particle Therapy at the West German Proton Therapy Centre Essen (WPE) is primarily studying children and adolescents with brain or skull base tumors who have undergone proton radiation therapy.
The research teams are investigating what happens in the brain after radiation therapy and why some patients continue to suffer from the treatment’s side effects—such as impaired concentration and memory—years later, even though proton therapy is gentler than conventional photon radiation. Read more
Your Responsibilities
- Conducting Monte-Carlo simulations of proton treatment plans
- Refinement of predictive models for risks of adverse events in proton therapy
- Cooperation with study nurses and the medical team in data collection and data review
- Coordination with partners at other locations of the consortium
- Oral presentations of research results and preparation of scientific publications


Your Qualifications:
- Completed Master’s degree in medical physics or physics
- Background in medical imaging or radiotherapy.
- Advanced IT and programming skills (e.g., Python, MATLAB)
- Good analytical skills and strong knowledge of statistical analysis
- English language skills at least on B2 level (German is a plus).
- Desirable, but not madatory: Dose simulation for radiotherapy & Radiation response modeling
Look forward to
- A challenging, diverse and application-oriented research in a highly qualified, interdisciplinary, open-minded and collegial team in one of Europe’s largest centres for proton therapy as well as practical experience in the physics team.
- You will work closely with a team of radiation therapy experts
- You will be part of a university, interdisciplinary environment with diverse scientific development opportunities
- Fair pay in accordance with the collective wage agreement (TV-Länder)

Apply now! And become a research assistant at the UncovRT-Project!
Please send your informative application documents with cover letter, CV, certificates and letter of motivation by 15th June 2026 to wpe-jobs@uk-essen.de
Prof. Dr. Christian Bäumer
West German Proton Therapy Centre Essen (WPE)
Universitätsklinikum Essen
Hufelandstraße 55
45147 Essen, Germany
Further information:
Applications from people of all genders are expressly welcome. Applications from women will be given preferential treatment in accordance with regulations. Measures to promote gender equality in science and, if necessary, to create a more family-friendly workplace are supported.
Please note that applications from suitable severely disabled persons are welcome.
Proton therapy

Radiation therapy with protons is considered to be particularly gentle. We have summarized the background and mode of action of proton therapy on this page.
Tumours treatable

Thanks to our expertise and intensive collaboration with the various disciplines at Essen University Hospital, we are able to irradiate a large number of tumors with proton therapy at the WPE.
Interdisciplinarity

At the West German Proton Therapy Centre, different professional groups work together to provide the best therapy for patients. Various team events are held together.