Below we have compiled information about the possibilities for the treatment of sarcomas with the aid of proton therapy (PT). At the present time, we treat all benign and malignant tumours with which no large metal implants have been placed and are not subject to breathing movement. As a rule, these are sarcomas of the base of the skull, facial skull, trunk, spine and pelvis. These can be different sub-types of tumours of the soft tissues, bone, or cartilagenous and connective and supporting tissue, such as rhabdomyosarcomas, osteosarcomas, Ewing sarcomas, or ochondrosarcomas. As a rule, a preoperative irradiation is no exclusion criterion. Nevertheless, here the possibility of repeating irradiation must be carefully examined in relation to the old irradiation documentation. The therapy options and the course of the therapy at our centre are always oriented to the individual clinical picture of each patient.