Prof. Dr. rer. nat. Cläre von Neubeck -

Prof. Dr. rer. nat. Cläre von Neubeck

Area of Expertise	Translational Particle Therapy
Title	Prof. Dr. rer. nat. Dipl.-Ing. for biotechnology
Core Area	Research focus Particle Radiation (investigating the relative biological effectiveness (RBE) in mono/ co-cultures, organotypic models, organ slice cultures and animal models) Experimental radiotherapy (investigating in established and primary tumor models in vivo/ ex vivo, biomarkers for radiosensitivity, tumor micromilieu, and combined radio-oncological therapy modalities) Animal studies Applicant since 2012, principle investigator since 2017 Mouse models: NMRI nu/nu, C3H, C57BL/6 Tumor models: human primary & established Glioblastoma multiforme and head/neck squamous cell carcinoma subcutaneous and orthotopically transplanted, injection of organoid cultures from GI tract Irradiation experiment with X-rays, photons, protons and heavier ions Animal studies investigated I) the DNA repair protein γH2AX as a predictive marker for the intrinsic radiosensitivity, II) the local tumor control following radio(chemo)therapy, III) the cancer stem cell population of tumor cultures via a Limited Dilution Assay, IV) the immunogenicity of tumor models and V) the tumor micromilieu and hypoxia
Memberships	German Society of Biological Radiation Research (DeGBS) German Society for Radiation Oncology (DEGRO) Radiation Research Society (RRS) European Radiation Research Society (ERRS)