Prof. Dr. rer. nat. Cläre von Neubeck

Junior professorship for translational particle therapy

Area of Expertise
  • Translational Particle Therapy
Title
  • Prof. Dr. rer. nat.
  • Dipl.-Ing. for biotechnology
Core Area Research focus
  • Particle Radiation (investigating the relative biological effectiveness (RBE) in mono/ co-cultures, organotypic models, organ slice cultures and animal models)
  • Experimental radiotherapy (investigating in established and primary tumor models in vivo/ ex vivo, biomarkers for radiosensitivity, tumor micromilieu, and combined radio-oncological therapy modalities)
Animal studies
  • Applicant since 2012, principle investigator since 2017
  • Mouse models: NMRI nu/nu, C3H, C57BL/6
  • Tumor models: human primary & established Glioblastoma multiforme and head/neck squamous cell carcinoma subcutaneous and orthotopically transplanted, injection of organoid cultures from GI tract
  • Irradiation experiment with X-rays, photons, protons and heavier ions
 
  • Animal studies investigated I) the DNA repair protein γH2AX as a predictive marker for the intrinsic radiosensitivity, II) the local tumor control following radio(chemo)therapy, III) the cancer stem cell population of tumor cultures via a Limited Dilution Assay, IV) the immunogenicity of tumor models and V) the tumor micromilieu and hypoxia
Memberships
  • German Society of Biological Radiation Research (DeGBS)
  • German Society for Radiation Oncology (DEGRO)
  • Radiation Research Society (RRS)
  • European Radiation Research Society (ERRS)